APPENDIX
Classification of Selected Enzymes with Clinical Importance According to the Enzyme Commission (EC) and Their
Common Names
TABLE V-l
EC Code
Systematic Name
Common Name (with Some Abbreviations)
1
Oxidoreductases
1.1
Acting on CHOH groups
1.1.1
With NAD+ or NADP+ as hydrogen acceptor
1
.
1
.
1.1
alcohol :NAD+ oxidoreductase
Alcohol dehydrogenase (AD)
1.1.1.14
L-iditol:NAD+ oxidoreductase
Sorbitol dehydrogenase (SD or ID)
1.1.1.27
L-lactate:NAD+ oxidoreductase
Lactate dehydrogenase (LD or LDH)
1.1.1.37
L-malate:NAD+ oxidoreductase
Malate dehydrogenase (MD)
1.1.1.42
threo-Ds-isocitrate-NAD+ oxidoreductase
(decarboxylating)
Isocitrate dehydrogenase (ICD)
1.1.1.44
6
-phospho-D-gluconate: NADP+ 2-oxido-
reductase (decarboxylating)
Phosphogluconate dehydrogenase
1.1.1.49
D-glucose
6
-phosphate: NADP+
Glucose-
6
-phosphate dehydrogenase
1
-oxidoreductase
(GDP or G
6
PD)
1.2
Acting on aldehyde or keto groups
1
.
2.1
With NAD+ or NADP+ as acceptor
1
.
2
.
1.12
D-glyceraldehyde 3-phosphate:NAD+
Glyceraldehydephosphate (triosephosphate)
oxidoreductase (phosphorylating)
dehydrogenase
1.4
Acting on CH-NH
2
groups
1.4.1
With NAD+ or NADP+ as acceptor
1.4.1.3
L-glutamate:NAD(P) dehydrogenase
(deaminating)
Glutamate dehydrogenase
1.6
Acting on NADH or NADPH
1.6.4
With a disulfide as acceptor
1.6.4.2
NAD(P)H:glutathione oxidoreductase
Glutathione reductase
2
Transferases
2.1
Transferring one-carbon groups
2.1.3
Carboxyl- and carbamoyltransferases
2.1.3.3
CarbamoylphosphatetL-omithine
carbamoyltransferase
Ornithine carbamoyltransferase (OCT)
2.3
Amino acid transferases
2.3.2.2
y-glutamy
1
-peptide:amino acid
y-glutamyl transferase
y-Glutamyltransferase (GGT or y-GT)
2.6
Transferring nitrogenous groups
2
.
6.1
Aminotransferases (transaminases)
2
.
6
.
1.1
L-aspartate:2-oxoglutarate
Aspartate aminotransferase (AST) (also
aminotransferase
known as glutamate oxaloacetate transaminase, GOT)
2
.
6
.
1.2
L-alanine:
2
-oxoglutarate
Alanine aminotransferase (ALT) (also known
aminotransferase
as glutamate alanine transaminase, GPT)
2.7
Transferring phosphorus-containing groups
2.7.1
Phosphotransferases with alcohol group
as acceptor
2.7.1.1
ATP:D-hexose
6
-phosphotransferase
Hexokinase (HK)
2.7.1.40
ATP:pyruvate 2-0-phosphotransferase
Pyruvate kinase (PK)
2.7.3
Phosphotransferases with nitrogenous
group as acceptor
2.13.2
ATPxreatine N-phosphotransferase
Creatine kinase (CK) (also known as
creatine phosphokinase, CPK)
2.7.4
Phosphotransferases with
phospho-group as acceptor
2.7.4.3
ATP: AMP phosphotransferase
Adenylate kinase
2.7.5
Phosphotransferases catalyzing
intramolecular transfers
(continued)
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